By using a genetic technique developed at UT Southwestern Medical Center that forces cells to rid themselves of mitochondria, researchers are gaining new insights into the function of these critical ...

Unlike other organelles (miniature organs within the cell), mitochondria have two membranes, an outer one and an inner one. Each membrane has different functions.

Most mitochondrial and all integral MOM proteins are encoded in the nucleus, imported into mitochondria and sorted inside the organelle to their correct location. Proper positioning of proteins is ...

Hypothesis: In this communication, we test the hypothesis that sulfotransferase 1C2 (SULT1C2, UniProt accession no. Q9WUW8) can modulate mitochondrial respiration by increasing state-III respiration.

Using super-resolution microscopy, here we show that cytosolic IMM vesicles, devoid of outer mitochondrial membrane or mitochondrial matrix, are formed during resting state.

Credit: Technology Networks. Outer membrane: The outer membrane is permeable to ions and small proteins due to the abundance of large conductance channels, known as voltage-dependent anion channels ...

Graphical AbstractRBX2 and CUL (cullin) 5, 2 core components of CRL5, localize to mitochondria. Depletion of RBX2 inhibited mitochondrial ubiquitination and turnover, impaired mitochondrial membrane ...

Dwindling NiMA. Through a cranial window, two-photon microscopy captured mitochondrial activity up to 80 minutes after stimulation. It rose (blue puncta) in 2-, but not 4- or 6-month-old APPSAA mice.

Mitochondrial outer membrane permeabilisation (MOMP) is often essential for apoptosis, by enabling cytochrome c release that leads to caspase activation and rapid cell death. Recently, MOMP has been ...

Mitochondrial inner membrane potential is a key factor determining several mitochondrial functions, i.e. respiration and protein import, and, thus, affects cellular metabolism. The study identifies a ...

The soluble Bax protein is responsible for the clearance of old or diseased cells, and when activated, it perforates the cell mitochondrial outer membrane to form pores that trigger programmed ...

The mitochondria in a cell contain two membranes: an outer membrane and an inner membrane (Figure 1). Both of these membranes are very important to the functioning of the organelle. The outer membrane ...