Researchers have revealed the mechanism underlying GPCR function using a GPS nuclear magnetic resonance (NMR) technique.

A research group has discovered that certain naturally occurring peptides in the body can trigger contractions in the vas ...

This important study investigated whether the nuclear receptor Nur77 is regulated by a non-canonical mechanism of ligand-induced disruption of its interaction with RXRg, similar to the family member ...

Data for SKYSCRAPER-01, involving the anti-TIGIT antibody tiragolumab, align with recent bad news for this once-promising ...

Kanazawa University, have captured real-time footage showing how a key hormone receptor activates genes, offering a clearer view of one of the most fundamental processes in biology.

GPCRs (G protein-coupled receptors), also known as 7 transmembrane domain receptors ... GPCRs share a conserved 7 transmembrane domain structure with an extracellular-facing ligand binding site and an ...

The substrate-binding ... with ligand and nucleotide binding and visualize key differences in how substrates and inhibitors interact with the TMD. They highlight the concerted TM and NBD movements ...

However, whether RNA-mediated TF binding results in differential transcriptional outcomes remains unknown. In this study, we demonstrate that estrogen receptor α (ERα), a ligand-activated TF, ...

Abstract: Predicting protein-ligand binding affinity is important in areas such as drug discovery, gene regulation and signal transduction. The DTA(Drug-Target Affinity) method based on protein ...