News

eLife7d
Defined cellular reprogramming of androgen receptor-active prostate cancer to neuroendocrine prostate cancer
The study by Li et al. provides fundamental findings supported by convincing evidence that they defined cellular reprogramming of androgen receptor in neuroendocrine prostate cancer (NEPC). The ...
TMCnet14d
Kanazawa University Research: Visualizing the Mechanics of Hormone-Driven Gene Activation: Insights into Breast Cancer
KANAZAWA, Japan, April 23, 2025 /PRNewswire/ -- Scientists at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University have captured real-time footage showing how a key hormone receptor ...
eLife15d
Identification of the Regulatory Elements and Protein Substrates of Lysine Acetoacetylation
This useful study reports a method to detect and analyze a novel post-translational modification, lysine acetoacetylation (Kacac), finding it regulates protein metabolism pathways. The study unveils ...
The EMBO Journal20d
Disrupted glucocorticoid receptor cell signalling causes a ciliogenesis defect in the fetal mouse renal tubule
RNA sequencing of E18.5 kidneys from glucocorticoid receptor (GR) null mice identified significant reductions in key ciliogenesis-related genes including Ccp110, Cep97, Cep290 and Kif3a. Confocal ...
ahajournals.org27d
Pathways and Molecular Mechanisms Governing LDL Receptor Regulation
Division of Cardiology, Department of Medicine, University of California, Los Angeles (H.M.S., K.E.J., T.Q.d.A.V., E.J.T.). Division of Cardiology, Department of ...
C&EN28d
Computation of Protein–Ligand Binding Free Energies with a Quantum Mechanics-Based Mining Minima Algorithm
A new method, protein–ligand QM-VM2 (PLQM-VM2), to calculate protein–ligand binding free energies by combining mining minima, a statistical mechanics end-point-based approach, with quantum mechanical ...
C&EN29d
Look What You Made Me Do: Discerning Feature for Classification of Endocrine-Disrupting Chemical Binding to Steroid Hormone Receptors
Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard-Karls-Universität Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany Tübingen Center for ...