Cysteinyl leukotrienes (CysLTs) are potent bronchoconstrictors, playing pivotal roles in inflammatory diseases. These lipid mediators exert their effects by activating two G protein-coupled receptors, ...

The data convincingly show that the transcription factor Sp1 regulates ephrin-mediated axon guidance in the spinal cord. Although the authors show that Sp1 and its co-activators p300 and CBP are ...

Nuclear receptors form a family of proteins capable of accommodating a wide variety of small molecules in their ligand binding domain, ranging from therapeutic compounds to endocrine-disrupting ...

One essential component in managing blood glucose levels is the insulin binding receptor, which plays a vital role in ... sugar testing devices rbs in blood normal range blood sugar regulation ...

Understanding how molecules interact with ions is a cornerstone of chemistry, with applications from pollution detection and ...

Research into transcription factors deepen understanding of the 'language' of the genome, offering insights into human development.

Here, we explored how NMDARs signal in tLTD. We found that, regardless of frequency, L5 PC→PC tLTD relies on the non-ionotropic preNMDAR signaling pathway mediated by JNK2, which helps to resolve the ...

Historical trends and future projections of the number of people with overweight and obesity suggest alarming parallel ...

Abstract: Predicting protein-ligand binding affinities is a critical problem in drug discovery and design. A majority of existing methods fail to accurately characterize and exploit the geometrically ...