Receptor tyrosine ... an optimal stimulation of the Rac1 pathway and subsequent cell motility. As it is not due to a different strength in c-Met activation/tyrosine phosphorylation (see ...

Receptor tyrosine kinases (RTKs ... for RTKs in part due to an emphasis on the discovery of ATP-competitive tyrosine kinase domain inhibitors. Biased ligands hold therapeutic promise due to ...

Growth of Kym-1 rhabdomyosarcoma cells depends on endogenous receptor tyrosine kinase signals activated ... dominance of TNF over mitogenic signal pathways in Kym-1 cells. In accordance with ...

in the activation loop of Fms-like tyrosine kinase 3 (FLT3). In Panel C, BCR-ABL exemplifies the fusion of receptor and nonreceptor TKs to various N-terminal partner proteins as a consequence of ...

Upon binding with an external ligand, the cytoplasm domain of the receptor tyrosine kinase undergoes autophosphorylation and becomes active, initiating a cascade of signaling pathways that result ...

The Understanding the Pathway article by Wiestner, entitled "Targeting B-Cell Receptor Signaling for Anticancer Therapy: The Bruton's Tyrosine Kinase Inhibitor Ibrutinib Induces Impressive Responses ...

AbbVie's Emrelis is the first non-small cell lung cancer therapy approved for patients with high c-Met expression levels who ...

Because the signaling pathways activated by several tyrosine kinase receptors have been shown to be involved in lung fibrosis, it has been suggested that the inhibition of these receptors may slow ...