Hyper-elevated levels of RNAPII on these histone genes indicate cancer over-proliferation and potentially contribute to chromosomal changes. These findings point to the use of a new genomic ...

In the study, published today in Science, the researchers discovered that the amount of a specific enzyme, RNA Polymerase II (RNAPII), found on histone genes was associated with tumor aggressiveness ...

Using a new technology and computational method, researchers have uncovered a biomarker capable of accurately predicting outcomes in meningioma brain tumors and breast cancers. Using a new ...

In the study, published today in Science, the researchers discovered that the amount of a specific enzyme, RNA Polymerase II (RNAPII), found on histone genes was associated with tumor ...

In the study, published today in Science, the researchers discovered that the amount of a specific enzyme, RNA Polymerase II (RNAPII), found on histone genes was associated with tumor ...

ICP22 condensates depleted the serine-2 phosphorylated RNA polymerase II (RNAPII Ser-2P) occupancy from the host transcription start site (TSS), resulting in decreased host transcripts output. At the ...

Our results demonstrate that p53 and RNAPII mediate extensive chromatin interactions within the Ad-p53 vector, resulting in the formation of a distinct 3D structure characterized by three prominent ...

Department of Molecular Medicine and Cancer Research Centre, Université Laval, Quebec, QC G1V 0A6, Canada CHU de Québec Research Centre, Quebec, QC G1V 4G2, Canada PROTEO-Quebec Network for Research ...