The expression of symptoms of viral infections is a byproduct of complex virus-host molecular pathways. These remain largely ...

Researchers unveil the fractal globule structure of DNA, providing new insights into genome organization and its implications ...

Currently, the researchers are using CRISPR-TO to move endogenous RNAs – RNA molecules that are naturally produced within the ...

During this process, the RNA editing enzyme ADAR1 was expressed and transformed into an isoform with an altered protein structure and function. Notably, the RNA editing activity of ADAR1, which ...

The wiring diagram and its data, freely available through the MICrONS Explorer, are 1.6 petabytes in size (equivalent to 22 years of non-stop HD video), and offer never-before-seen insight into ...

This method not only extracts deep contextual information from RNA sequences but also incorporates structural and functional knowledge for a more comprehensive semantic representation. By enhancing ...

With the increase in RNA data, structure predictions have evolved from conventional to advanced computational methods. Various bioinformatics methods have been developed to predict RNA structures to ...

The human immunodeficiency virus (HIV-1) is highly dependent on a variety of host factors. Beside proteins, host RNA molecules are reported to aid HIV-1 replication and latency maintenance. Here, we ...

The second is small-molecule-guided methods, which typically target RNA in a structure-dependent manner. While distinct in the targeting strategy and the sphere of applicability, they share much in ...

NuFold is a state-of-the-art method designed for predicting 3D RNA structures, leveraging deep learning for high accuracy and reliability. This tool is particularly useful for biologists and ...

The biological function of RNA, however, is often determined by the degree of structure it displays. One way in which small molecules can be targeted specifically is by binding to the pockets ...