Chemists at UCL and the MRC Laboratory of Molecular Biology have demonstrated how RNA (ribonucleic acid) might have ...

Chemists have demonstrated how RNA (ribonucleic acid) might have replicated itself on early Earth -- a key process in the origin of life.

Somatic hypermutation (SHM) of immunoglobulin variable (V) regions modulates antibody-antigen affinity is initiated by activation-induced cytidine deaminase (AID) on single-stranded DNA (ssDNA).

On the other hand, EZH1 is essential for circadian gene expression at alternate Zeitgeber times, through stabilization of RNA Polymerase ... states and RNA Pol II complex stability. Reciprocal ...

RNA polymerase II 3 transcribes protein-coding genes into messenger RNA (mRNA). This 12-subunit enzyme works as a complex that directly influences gene expression through its production of pre-mRNA ...

Thus, chromatin-based control of the Pol II elongation rate is a potential mechanism to regulate alternative polyadenylation in response to genetic or environmental changes. The RNA polymerase II ...

A great deal of work has revealed, in structural detail, the components of the preinitiation complex (PIC) machinery required for initiation of mRNA gene transcription by RNA polymerase II (Pol II).

Five of these are core subunits which form crab claw shapes with DNA at their centres, channels for RNA products ... site with RNAP II, forming the transcription initiation complex (TIC).

During transcription elongation, the RNA polymerase II complex "walks" along one strand of DNA, copying genetic elements to a strand of RNA. Shilatifard's laboratory has previously discovered ...

RNA polymerase II, or Pol II, doesn’t start working on its own. Transcription factors first bind to the DNA, forming a complex that ... key piece of biological machinery assembles and how ...

It is conceivable that TFII-I recruits the Brg1 chromatin remodeling complex to these ... the recruitment of Pol II or stimulate the elongation step of transcription. The poised state may also involve ...