News

Early Earth chemistry: Triplet RNA building blocks and freeze-thaw cycles enable self-replication in water
Chemists at UCL and the MRC Laboratory of Molecular Biology have demonstrated how RNA (ribonucleic acid) might have ...
eLife6d
Somatic hypermutation patterns in immunoglobulin variable regions are established independently of the local transcriptional landscape
Somatic hypermutation (SHM) of immunoglobulin variable (V) regions modulates antibody-antigen affinity is initiated by activation-induced cytidine deaminase (AID) on single-stranded DNA (ssDNA).
C&EN23d
Structure of Microcin J25, a Peptide Inhibitor of Bacterial RNA Polymerase, is a Lassoed Tail
Contribution from the Laboratory of Molecular Biophysics, Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, and Laboratory of Synthetic Protein Chemistry, The Rockefeller University, New York ...
Yale Environment 36023d
Yale-developed method offers view into earliest stages of RNA production
When RNA molecules are synthesized by cells — a critical process in the creation of proteins and other cellular functions — they typically undergo a series of “folding” events that determine their ...
C&EN26d
Pt(II)-NHC Complex Induces ROS-ERS-Related DAMP Balance to Harness Immunogenic Cell Death in Hepatocellular Carcinoma
Get article recommendations from ACS based on references in your Mendeley library. Pair your accounts. Export articles to Mendeley Get article recommendations from ACS based on references in your ...
The EMBO Journal27d
Molecular basis for assembly and activation of the Hook3 − KIF1C complex-dependent transport machinery
This study reveals how Hook3 serves as a mechanical platform for assembling cargo transport machinery. Hook3 forms a 2:2 heterotetrameric complex with KIF1C. KIF1C competitively interacts with PTPN21 ...