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Early Earth chemistry: Triplet RNA building blocks and freeze-thaw cycles enable self-replication in water
Chemists at UCL and the MRC Laboratory of Molecular Biology have demonstrated how RNA (ribonucleic acid) might have ...
C&EN2d
Interaction of the Histone mRNA Hairpin with Stem–Loop Binding Protein (SLBP) and Regulation of the SLBP–RNA Complex by Phosphorylation and Proline Isomerization
There are two binding sites in the SLBP RNA binding domain for the histone mRNA hairpin ... We show that the SLBP–histone mRNA complex is regulated by threonine phosphorylation and proline ...
C&EN5d
Exceptionally Active Assembled Dinuclear Ruthenium(II)-NNN Complex Catalysts for Transfer Hydrogenation of Ketones
† Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, Liaoning 116023, China ‡ University of Chinese Academy of Sciences, Beijing 100049, China § State Key ...
eLife6d
Somatic hypermutation patterns in immunoglobulin variable regions are established independently of the local transcriptional landscape
Somatic hypermutation (SHM) of immunoglobulin variable (V) regions modulates antibody-antigen affinity is initiated by activation-induced cytidine deaminase (AID) on single-stranded DNA (ssDNA).