Recognition of the core promoter by the transcription machinery is essential ... Figure 3: The ten-subunit yeast RNA Pol II structure and structure of the elongation complex.

The Pre-Initiation Complex (PIC), which consists of Mediator, TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA polymerase II (pol II), governs the expression of all protein-coding and most non-coding ...

However, RNA polymerase II (Pol II) initiation factors and the 3′-end processing and termination machinery are more intertwined than one might expect 110, and several recent papers provide new ...

RNA polymerase II 3 transcribes protein-coding genes into messenger RNA (mRNA). This 12-subunit enzyme works as a complex that directly influences gene expression through its production of pre-mRNA ...

Scientists have recently uncovered the mechanisms of how RNA polymerase II performs intrinsic cleavage ... Huang's research interest lies in understanding complex biological and chemical processes ...

RNA polymerase II, or Pol II, doesn’t start working on its own. Transcription factors first bind to the DNA, forming a complex that ... key piece of biological machinery assembles and how ...

Mediator is a common target of DNA-binding transcription factors (TFs) and also interacts with various Pre-Initiation Complex (PIC) factors. The PIC consists of TFIIA, TFIIB, TFIID, TFIIE, TFIIF, ...

During transcription elongation, the RNA polymerase II complex "walks" along one strand of DNA, copying genetic elements to a strand of RNA. Shilatifard's laboratory has previously discovered ...

Scientists at the Morgridge Institute for Research and the University of Wisconsin–Madison have captured strikingly improved images of the machinery ... complex functions. For instance, they found ...