Researchers engineered a new gene system in the parasite A. deanei using a bacteriophage enzyme and novel drug markers. This ...

STONY BROOK, NY / ACCESS Newswire / May 29, 2025 / Applied DNA Sciences, Inc. (NASDAQ:APDN) (“Applied DNA” or the “Company”), ...

Somatic hypermutation (SHM) of immunoglobulin variable (V) regions modulates antibody-antigen affinity is initiated by activation-induced cytidine deaminase (AID) on single-stranded DNA (ssDNA).

“Instead, we discovered that these phosphorylation sites work together but have distinct and opposing effects on RNA polymerase II elongation speed and the output of RNA.” The study used a ...

Like mRNA, the majority of lncRNAs are polyadenylated and transcribed by RNA polymerase II. Loci that produce lncRNAs have many features similar to protein-coding genes, promoters, alternative ...

RNA polymerase II (RNA Pol II) speed or elongation rate, i.e., the number of nucleotides synthesized per unit of time, is a major determinant of transcriptome composition. It controls ...

Drug developers & researchers can now leverage the CleanScribe enzyme to reduce dsRNA formation by up to 85% in mRNA synthesis without compromising mRNA yield, capping efficiency, or integrity ...

RNA polymerase II 3 transcribes protein-coding genes into messenger RNA (mRNA). This 12-subunit enzyme works as a complex that directly influences gene expression through its production of pre-mRNA ...

Thus, chromatin-based control of the Pol II elongation rate is a potential mechanism to regulate alternative polyadenylation in response to genetic or environmental changes. The RNA polymerase II (Pol ...

RNAP II is the enzyme primarily responsible for the synthesis of messenger RNA (mRNA). RNAP I and III contain an extra heterodimeric subunit. RNAP III alone has a heterotrimeric subunit ...

United Kingdom Transcription by RNA polymerase II (Pol II) is regulated by different processes, including alterations in chromatin structure, interactions between distal regulatory elements and ...