CRISPR-Cas12a is a programmable endonuclease used for genetic engineering ... and reversible steps to test for matches with its guide RNA molecule. CRISPR-Cas13 RNA-targeting systems comprise ...

A research team has identified NEAT1, a long non-coding RNA, as a key player in DNA repair. This discovery links RNA metabolism to genome stability and opens up potential new cancer treatments. Credit ...

This month's cover highlights the article Natural variations of adolescent neurogenesis and anxiety predict the hierarchical status of adult inbred mice by Nicolas Toni, Thomas Larrieu and colleagues.

These gene detection techniques based on LbCas12a are named DETECTR (DNA Endonuclease Targeted CRISPR Trans Reporter). The principle of DETECTR is similar to SHERLOCK. Cas13a recognizes target RNA and ...

Type I and Type III TA systems are unique in that the antitoxin in these systems is an RNA molecule, whereas the antitoxin in all other TA systems is a protein. Though hotly debated, the involvement ...

A metallo β-lactamase (MBL) fold enzyme, cleavage and polyadenylation specificity factor 73 (CPSF73), is proposed to be the sole endonuclease responsible for 3' end processing of both mRNA classes. We ...

Here, we show that E2 stimulation causes a rapid, global increase in the formation of R-loops, co-transcriptional RNA-DNA products, which in some instances have been linked to DNA damage. We show that ...