Researchers have engineered a compact, high-specificity IscB variant, NovaIscB, for safe, persistent in vivo epigenome ...

The yeast nuclear endonuclease Rnt1 has a well-characterized role in the maturation of many ncRNA precursors. However, the scope and consequence of its function in mRNA degradation pathways is much ...

When RNA molecules are synthesized by cells — a critical process in the creation of proteins and other cellular functions — they typically undergo a series of “folding” events that determine their ...

Through international collaboration, researchers at KAIST have revealed that RNA editing plays a crucial role in regulating neuroinflammation, a key pathology of Parkinson's disease. KAIST ...

Stanford Medicine researchers have developed a blood test capable of detecting cancers, the ways cancer resists treatments and tissue injury caused by non-cancerous conditions. The new test ...

Get Instant Summarized Text (Gist) A long-read RNA sequencing dataset comprising 750 million reads across 14 human cell lines enables direct observation of full-length RNA molecules, overcoming ...

The researchers tested the RNA origami in a lipid vesicle, a simple cell model system widely used in biology. Using so-called RNA aptamers, the artificial cytoskeleton was bound to the cell membranes.

COVID-19 RNA may induce monocytes to develop cancer-fighting properties, potentially shrinking tumors in certain metastatic cancers. Patients resistant to prior immunotherapy showed the most benefit ...

Regeneron is integrating single-use chromatographic clarification into its commercial-scale process for manufacturing adeno-associated vectors (AAVs), which enables it to eliminate endonuclease in ...

The ENCODE work, using techniques that could map RNA activity happening along genome sections, had begun in 2003 and came up with preliminary results in 2007. But not until five years later did ...

First, we construct and observe the appearance of a long branch in the phylogeny based on homodimeric endonuclease. To appreciate the finer aspects of accelerating evolution near this long branch, we ...