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C&EN2d
Proteome-Wide Characterization of the RNA-Binding Protein RALY-Interactome Using the in Vivo-Biotinylation-Pulldown-Quant (iBioPQ) Approach
RALY is a member of the heterogeneous nuclear ribonucleoproteins, a family of RNA-binding ... interacting proteins, we confirmed RNA-dependent interactions of RALY with MATR3, PABP1 and ELAVL1.
EurekAlert!24d
RNA-binding proteins and circular RNAs: A new frontier in cancer therapy
The interaction between circular RNA (circRNA) and RNA-binding protein (RBP). Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and authoritative reviews that ...
EurekAlert!1mon
A new druggable cancer target: RNA-binding proteins on the cell surface
Extending this discovery recently in Cell, Flynn and colleagues showed that glycoRNAs form highly organized clusters with RNA-binding proteins on the cell surface. These clusters appear to ...
The Scientist2mon
RNA-binding proteins
An RNA-modifying enzyme passed to daughter cells during budding ... Discover Biotium’s new RNaseReveal™ Activity Assay Kit—ultrasensitive RNase detection with a fast, easy protocol to streamline your ...
The EMBO Journal5mon
RNA-binding proteins hnRNPM and ELAVL1 promote type-I interferon induction downstream of the nucleic acid sensors cGAS and RIG-I
Combining interactome analysis with genome editing, we further uncover the RNA-binding protein ELAV-like protein 1 (ELAVL1 ... as interaction of ELAVL1 with hnRNPM and IKKε decreased upon RNase A ...
BioSpace9mon
RNA Therapeutics Receives Feedback from FDA for the First-in-class mRNA-based Delivery of Therapeutic Protein Promising Affordable Biological Drugs
CHICAGO, Aug. 19, 2024 /PRNewswire/ -- RNA Therapeutics, a clinical-stage biotechnology company focused on innovative applications of mRNA-based delivery systems for therapeutic proteins and vaccines, ...
eLife1y
Two RNA-binding proteins mediate the sorting of miR223 from mitochondria into exosomes
The sorting of one exosomal cargo RNA ... N-tosyl-L-phenylalanine chloromethyl ketone and 1 µg/ml pepstatin) and RNase inhibitors, followed by centrifugation at 12,000 g for 10 min. Supernatant ...
News Medical2y
Scientists study OAS–RNase L errors and COVID-19-associated multisystem inflammatory syndrome in children
Study: Inborn errors of OAS–RNase L in SARS-CoV ... cytosolic proteins, which generate 2′-5′-linked oligoadenylate (2-5A) after binding to double-stranded (ds) RNA. In turn, the 2-5A ...
eLife4y
Controlling bacterial mRNA
Each sRNA can bind to several specific mRNA targets, and lead to their degradation by an enzyme called RNase E. Certain bacterial RNA-binding proteins, such as Hfq, protect sRNAs from being degraded, ...
Frontiers5y
RNA-Binding Proteins Driving the Regulatory Activity of Small Non-coding RNAs in Bacteria
Ribonucleases (RNases) can be considered a class of RNA-binding proteins with nucleolytic activity that are responsible for RNA maturation and/or degradation. Presently RNase E, RNase III, and PNPase ...
ahajournals.org5y
Cold-Inducible RNA-Binding Protein Prevents an Excessive Heart Rate Response to Stress by Targeting Phosphodiesterase
As an RNA-binding protein, CIRP (cold-inducible RNA-binding protein ... and then measured the diluted library and adjusted the concentration to 5 nmol/L. Final libraries were pooled and sequenced on ...