Here, we show that overexpression of RNase L decreases cellular growth and downmodulates the RNA-binding protein, HuR, a regulator of cell-cycle progression and tumorigenesis. The effect is ...

RNase L can form a heterodimer with the RNase L inhibitor protein (RLI) 16,17 and with an RNA-binding protein (RNABP) 18,19. The association of RNase L and RNABP has been observed in different ...

The RNA-binding protein PUM2 impairs mitochondrial dynamics and mitophagy during aging. Molecular Cell , 2019; DOI: 10.1016/j.molcel.2018.11.034 Cite This Page : ...

An RNA-modifying enzyme passed to daughter cells during budding ... Discover Biotium’s new RNaseReveal™ Activity Assay Kit—ultrasensitive RNase detection with a fast, easy protocol to streamline your ...

In some systemic autoimmune diseases, antibodies target nuclear proteins bound ... that the efficacy of RNase-based treatments depends on the localization of the RNA-binding site,” says Ryota ...

Led by Ryan Flynn, MD, PhD, assistant professor of stem cell and regenerative biology at Harvard Medical School (HMS), the study identified one RNA-binding protein on the cell surface, NPM1 ...

Study: Inborn errors of OAS–RNase L in SARS-CoV ... cytosolic proteins, which generate 2′-5′-linked oligoadenylate (2-5A) after binding to double-stranded (ds) RNA. In turn, the 2-5A ...

Researchers have identified key drivers of T cell development which promote resilience to influenza virus infection. Scientists at the Babraham Institute have shown that two RNA binding proteins ...

The interaction between RNA-binding proteins (RBPs) and circular RNAs (circRNAs) has emerged as a key area of interest in understanding cancer biology. As critical regulators of gene expression ...

Mutations in or mislocalization of RNA-binding proteins, such as TDP-43 and FUS, are linked to protein aggregation in frontotemporal dementia and amyotrophic lateral sclerosis. Now, researchers led by ...

A protein-RNA structure hints at how viruses commandeer human proteins Nov 11, 2015 RNA transport in neurons—Staufen2 detects its target transcripts in a complex manner ...