To explore the mechanisms behind this, the researchers looked at an enzyme called pyruvate dehydrogenase. This enzyme links the two stages of cellular respiration: glycolysis and the citric acid ...

The study uncovers a novel mechanism by which ING5 promotes the phosphorylation of pyruvate dehydrogenase kinase 1 (PDK1) at tyrosine 163 (Y163), thereby inhibiting the Warburg effect and reducing ...

DCA is a targeted therapy that inhibits Pyruvate Dehydrogenase Kinase (PDK) to stimulate residual Pyruvate Dehydrogenase Complex (PDC) activity and increase energy (ATP) production by mitochondria.

The intact structure of mammalian multi-enzymatic pyruvate dehydrogenase complex (PDHc) remains poorly understood. Through in-situ structural analysis, the authors unveil its intrinsic dynamics ...