“The discovery of the PKZILLAs and their role in prymnesin biosynthesis lays the foundation for the development and implementation of alternative linked omics approaches to fully uncover the ...

According to the findings, these massive PKS gigasynthases are responsible for the biosynthesis of the 90-carbon backbone of prymnesin toxins. The authors also characterized a variant, PKZILLA-B1 ...

In addition to identifying the massive proteins behind prymnesin, the study also uncovered unusually large genes that provide Prymnesium parvum with the blueprint for making the proteins. Finding the ...

Prymnesin belongs to a group of toxins called polyketide ... Giant polyketide synthase enzymes in the biosynthesis of giant marine polyether toxins. Science. 2024;385(6709):671-678. doi: ...

It is known for the toxin it produces, called prymnesin, which damages the gills of fish and other water-breathing animals. Prymnesin is part of the polyketide polyethers family, a notorious group of ...

Before finding PKZILLA, scientists were already closely familiar with prymnesin-1, an infamous toxin produced by P. parvum. The toxin is responsible for killing hundreds of thousands of fish ...

parvum as a simpler study system because it has a much smaller genome but produces a similar toxin, called prymnesin. “Because it's got a small genome, it could be a model system for these other ...

"It was therefore possible to test this prymnesin standard and other detected micropollutants as well as the water extracts directly," says Beate Escher. Even at very low concentrations in the ...

In addition to identifying the massive proteins behind prymnesin, the study also uncovered unusually large genes that provide Prymnesium parvum with the blueprint for making the proteins.