Complex protein interactions at synapses are essential for memory formation in our brains, but the mechanisms behind these processes remain poorly understood. Now, researchers have developed a ...

In the default model, the graph representing each individual enhancer can be arbitrarily complicated. To show how the ABC Score formula can arise from the default model, we need to impose the further ...

This useful study presents computational analyses of over 5,000 predicted extant and ancestral nitrogenase structures. While the data and some analyses are solid, the study remains incomplete in ...

Marking a breakthrough in the field of brain-computer interfaces (BCIs), a team of researchers from UC Berkeley and UC San Francisco has unlocked a way to restore naturalistic speech for people with ...

Every AI model trained for biology only can see what’s illuminated by the data points it is trained on. AlphaFold succeeded in predicting protein structures because the 200,000 or so known ...

Called NetFlow3D, the framework has been applied to 33 different cancer types, leveraging the 3D structures of every human protein and all ... the first to develop 3D models of proteins—a ...

However, existing methods have significant limitations—they often apply only to a narrow range of proteins, require genetic modifications, or risk damaging protein function due to nonspecific ...

The paleontologists say it was a stroke of good luck that the fossils were preserved in 3D, noting that they give a much clearer picture of what the dinosaur would have looked like when alive.

Introduction of protein-mononucleotide binding residues data sets ... ROC and PR curves of different features on training sets; Figure S3. Diagram of model ablation analysis. Figure S4. The ROC and PR ...

Xinjiang Engineering Research Center of Big Data and Intelligent Software, School of Software, Xinjiang University, Urumqi 830091, China Key Laboratory of Software Engineering, Xinjiang University, ...

Their sensory capacity relies on receptors, in particular G-protein-coupled receptors (GPCRs ... it remains unclear whether the epileptic phenotypes observed in ADGRV1-deficient models are primarily ...