To confirm that cleavage of full‐length YB‐1 in doxorubicin‐treated cells was mediated by proteasomes, we employed proteasome and calpain inhibitors such as MG132, Inhibitor I and ALLN as well as ...

The cellular waste disposal system called the proteasome is best known for its central role in protein degradation and recycling, but as far back as the 1990s it was shown that products of this ...

In fact, Diogo Feleciano, PhD, one of the co-founders and the CSO of a new biotech startup Booster Therapeutics said that his company’s proteasome activation approach offers important advantages ...

In an effort to find a new weak spot of this parasite, the research group led by Dr. Evžen Bouřa has succeeded in preparing a key enzyme complex – the proteasome. This has made it possible to ...

Recent research from the lab of Dr. Nicolas Lehrbach, an Assistant Professor in the Basic Sciences Division at Fred Hutch, discovered that altering nucleotide metabolism may bypass proteasome defects ...

but not calpain 2, in mouse hearts demonstrated substrate-specific proteolytic activity under basal conditions, with hyperubiquitination of cardiac proteins and increased 26S proteasome activity. Loss ...

Genome-wide DNA methylation status to predict the efficacy of modified (m)-FOLFOXIRI plus cetuximab as initial treatment for RAS wild-type metastatic colorectal cancer: A biomarker study of the DEEPER ...

While multiple protein degradation pathways exist—including the autophagy-lysosome, calcium-dependent calpain, and cysteine aspartate protease systems—the ubiquitin-proteasome pathway emerges as an ...

For more than a decade, medical providers have treated multiple myeloma (MM) with proteasome inhibitors (PIs). This important drug therapy has helped improve survival rates of people with MM.

Collectively, our work reveals that osmotic stress induces calpain- and proteasome-mediated vimentin degradation and IF network breakdown. These effects are significantly augmented in the presence of ...

Affar's team looked at a tiny biological machine called the proteasome that exists in every cell in the body. This machine is responsible for breaking down and removing unwanted, malformed or ...