Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, Dundee DD1 5JJ, U.K. Centre for Targeted Protein Degradation, School of Life Sciences, ...

"Cells have two important 'junk compartments': the lysosome and the proteasome," Silverman said. "They collect junk and other components that are not useful to the cell, chew them up and get rid ...

Weizmann Institute of Science In their experiments, the researchers forced the proteasome in human cells to confront Salmonella bacteria. The proteasome released tiny peptides that stopped the growth ...

Knockdown of p62 disrupts the formation of these ADPr condensates. Importantly, these structures are unaffected by autophagy inhibition, but depend on ubiquitination and proteasome activity. Taken ...

Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Citrus Research Institute, Southwest University, Chongqing 400712, China National Citrus Engineering ...

“Before now, we knew nothing about the connection between proteasome products and the production of these peptides,” Merbl, senior author of the study, said in a press statement. “In light ...

“Before now, we knew nothing about the connection between proteasome products and the production of these peptides,” Merbl, senior author of the study, said in a press statement. “In light ...

A model of the proteasome. Image credits: RCSB. For decades, the proteasome has been considered a simple molecular shredder. It chews up used or damaged proteins and feeds them to T cells to help ...

Autophagy is a cellular degradation process that plays a crucial role in maintaining metabolic homeostasis under conditions of stress or nutrient deprivation. This process involves sequestering, ...

As the world’s population ages, neurodegenerative diseases are becoming more widely acknowledged as serious global health and socioeconomic issues. Although many resources have been devoted to the ...