New research published in the journal Nature has revealed a previously unknown function of the proteasome, a component of cells once thought to only play a role in the degradation of proteins. A ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The prevailing view on post-translational ...

Calcium-activated proteolysis by calpain is a candidate to participate in this form of pathology because it is activated under ischemic conditions and its activation results in the degradation of ...

Proteasome-mediated proteolysis is important for synaptic plasticity, neuronal development, protein quality control, and many other processes in neurons. To define proteasome composition in brain, we ...

charite.de Objectives To investigate whether bortezomib, a proteasome inhibitor approved for treatment of multiple myeloma, induces clinically relevant plasma cell (PC) depletion in patients with ...

NF-κB activates ubiquitin-proteasome System (UPS) and degrades proteins by binding E1, E2, and E3, with Atrogin-1 and muscle-specific RING finger protein 1 (MuRF1) being the two most common E3s Ligase ...

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