After questioning the physician about the dose (100 mg is a high dose), she began administering the propofol via an infusion pump. The patient suddenly experienced respiratory arrest. Fortunately ...

The study drug infusion rate was adjusted to maintain a Ramsay sedation score of ≥3. Patients were allowed to receive “rescue” propofol as needed to augment the study drug infusion.

Because the optimal level of sedation was not achieved, the initial propofol infusion rate was increase to 3.5 mg/kg, and then an intravenous bolus of morphine (.01 mg/kg) was administered twice ...