In April 2025, three people in Oregon developed Creutzfeldt-Jakob disease (CJD), a rare, fatal neurological condition that is ...

Prion-like proteins can propagate across species, potentially contributing to disease. Here the gut microbiome was analyzed ...

In vitro structural studies have shown that misfolding and aggregation involve a large structural rearrangement of the protein, forming cross-β amyloid-like fibrils, which seems to be the common ...

Analysis of proteomic profiles of tumours and cell lines reveals that the abundance of a paralogous protein is often ...

Disease-associated prion protein (PrP Sc) accumulates in FDCs (ref. 6), which function as antibody- and complement-dependent antigen traps. Here we investigated whether the mechanisms by which ...