Cells are the smallest units of life. But even within the same tissue or organ, they are not all identical. New variations arise continuously during cell proliferation. While genetic mutations alter ...

Cancer cells respond to stress with greater diversity. Drugs that affect DNA replication, or radiation that causes direct DNA damage, lead to increasingly diverse offspring over multiple cell ...

The combination of real-time and endpoint measurements showed that different pathways towards polyploidy have different effects on the stability of the genome, thereby influencing the fitness of ...

in addition to the direct effects of the disruption. Panagopoulos et al. used their platform to probe other facets of genome instability, such as polyploidy (multiple copies of the genome in one ...

The effects on global gene expression were found to be cumulative ... the role of the triploid block in polyploid evolution, and the control of quantitative traits. Genomic imbalance refers to the ...

However, there is no discussion or quantification of polyploidy/multinucleation in the IDH1 deficient ... prohibiting the assessment of direct effects of IDH1 loss of function (only a degron approach ...

The National Institutes of Health (NIH) published research in June 2024 that considered the correlation between semaglutide therapy and "exacerbating mood disturbances." The study highlighted the ...

citing reports of side effects including sexual dysfunction and suicidal thoughts. The warning relates to a topical spray form of the drug finasteride, also known by the brand name Propecia.

While GLP-1 RA variants had “consistent cardiometabolic effects” across all groups, the researchers said the negative impacts on mental health were “more varied,” concluding that any behav ...