Purespring Therapeutics EMA designation provides orphan status to medicines being developed for rare conditions that are intended for the diagnosis, prevention or treatment of diseases affecting ...

Stephen J Tonna; Alexander Needham; Krishna Polu; Andrea Uscinski; Gerald B Appel; Ronald J Falk; Avi Katz; Salah Al-Waheeb; Bernard S Kaplan; George Jerums; Judy Savige; Jennifer Harmon; Kang ...

1038A>G polymorphisms in the NPHS2 gene between patients and controls (Table 6). In this study we investigated the possible role of the major slit diaphragm proteins, nephrin and podocin ...

The Company also has programmes for diseases caused by mutations in the gene NPHS2, as well as other monogenic glomerular kidney diseases. Based in London, the Purespring team combines world-leading ...

Chronic kidney disease (CKD) is a public health challenge that affects more than 800 million people worldwide. 1 CKD can be caused by a variety of disease processes. Many causes are difficult to ...

We identified 67 compounds, including 20 likely active compounds, in BSHX decoction. The podocyte markers, nephrin and podocin, were down-regulated, while the mesenchymal markers, α-SMA and FSP-1, ...

synaptopodin and podocin (Sigma-Aldrich), ICN1 (Val1744, Abcam), p53 or Cdkn1a (Santa Cruz), developed using FITC-conjugated anti-mouse secondary antibody or Cy3 conjugated anti-rabbit antibodies ...

We thank the Robert Wood Johnson Foundation (Grant no. 052746) for funding support and PNAS reviewers for helpful comments. This contribution is part of the special series of Inaugural Articles by ...

Morphologically distinguishable podocytes appear during the S‐shaped stage of nephron development at which stage the known podocyte markers Nphs2 and Podxl appeared in developing podocytes, together ...

To advance our understanding of development, function and diseases in the kidney glomerulus, we have established and large‐scale sequenced cDNA libraries from mouse glomeruli at different stages of ...