The platelet plasma membrane is literally at the cutting-edge of recent research into proteolytic regulation of the function and surface expression of platelet receptors, revealing new mechanisms for ...

The Host Trimethylamine Receptor TAAR5 Shapes Circadian Oscillations in Circulating Hormones and Cytokines.

Acute coronary syndrome (ACS) in patients with SARS-CoV-2 infection represents a critical intersection of viral-induced inflammation and cardiovascular pathology. This review explores the dual ...

platelet count ≥ 100,000/mm 3; total bilirubin ≤ 1.5× the upper limit of normal (ULN); ALT and AST ≤ 2.5× ULN, (liver metastases AST/ALT < 5× ULN); alkaline phosphatase ≤ 4× ULN; prothrombin ...

Platelet activation is a complex and dynamic process, involving the co-ordination of numerous receptors to initiate shape change and aggregation. Under pathological conditions, alterations in the ...

Megakaryocytes (MKs), known for their role in platelet production ... The review emphasizes the expression of immune receptors by MKs, such as toll-like receptors (TLRs), Fc gamma receptors ...

According to a recent study published in Thrombosis Research, thrombopoietin receptor agonists (TPO-RAs) may impact platelet function in patients with immune thrombocytopenia (ITP). “Our data suggest ...

The research team developed antibody fragments called nanobodies and crosslinked these to make ligands to four platelet receptors (GPVI, CLEC-2, FcɣRIIA and PEAR1). The nanobodies can be used to ...

Platelet-derived growth factor (PDGF ... and VEGFR2 protein expression. They found these receptors to be variably expressed amongst the investigated cell lines. Interestingly, whereas Caco ...

These events could be due to protein-protein interactions with plasma proteins that cause misfolding and platelet receptors that lead to hyperactivation. Impaired coagulation that contributes to ...