While immunotherapy with chimeric antigen receptor T (CAR-T) cells has shown much promise in haematological malignancies, their efficacy for solid tumours is challenged by the lack of tumour-specific ...

The new study found that Thetis cells not only help to broker peace accords with “good” bacteria, but also with proteins in foods that can act as allergens — such the Ara h proteins found in peanuts ...

Antigen-presenting cells rally T cells to the scene, launching an attack on the foreign tissue. These are the first steps of organ transplant rejection. Current immunosuppressants act like ...

Their study is based on a large-scale meta-analysis of single-cell RNA sequencing and T-cell receptor (TCR) sequencing from cancer patients treated with immunotherapy. This allowed them to examine ...

Department of Ultrasound, Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200001, P.R. China ...

A next-generation, anti-CD19 enhanced CAR T-cell therapy that secretes interleukin-18 achieved a response in 81% of lymphoma patients who failed previous CAR T-cell therapy. Duration of response ...

Chimeric antigen receptor (CAR) T cells targeting CD19 have transformed the treatment of B-cell cancers, but many patients do not have long-term remission. We designed an anti-CD19 enhanced ...

A new class of molecules capable of killing the cancer cells that are refractory to standard ... Orsay (CNRS/Université Paris-Saclay), Harvard T.H. Chan School of Public Health, Helmholtz Zentrum ...

Department of Chemistry, Kangwon National University, Chuncheon 24341, Republic of Korea Multidimensional Genomics Research Center, Kangwon National University, Chuncheon 24341, Republic of Korea ...

After spending years tracing the origin and migration pattern of an unusual type of immune cell in mice, researchers headed by a team at The Ohio State University College of Medicine have shown ...