Osteoclasts are formed through differentiation from a certain type of immune cell called macrophage, after which they acquire their new role in the maintenance of bones and joints: breaking down ...

Researchers have developed a novel compound that could be useful for treating bone-destructive diseases. Their study ...

The study demonstrated that MKK3 plays a crucial role in the late stage of osteoclast differentiation, specifically affecting the nuclear localization of p38-MAPK. This finding helps clarify the ...

Targeting osteoclast differentiation is therefore, a potential therapeutic strategy. In a new study, researchers have discovered a novel role of the Ctdnep1 phosphatase in suppressing osteoclast ...

Excessive osteoclast activity can lead to increased bone resorption, which contributes to osteoporosis. The findings revealed ...

A recent study by TUS researchers reveal that the Cpeb4 protein may have a role in regulating osteoclast differentiation. This, in turn, could lead to the development of new therapeutic drugs for ...

Osteoclasts resorb bone by secreting proteases ... more than 12 ng of DKK1 per milliliter inhibited osteoblastic differentiation in a murine myoblast cell line. These data suggest that DKK1 ...

During osteoclast differentiation, Ctdnep1 expression remains consistent, yet its depletion results in heightened osteoclast formation and activity. Mechanistically, Ctdnep1 demonstrates a ...