Researchers have developed a novel compound that could be useful for treating bone-destructive diseases. Their study ...

Bone-destructive diseases such as osteoporosis and chronic inflammatory arthritis affect millions of people worldwide, ...

He referenced preclinical data, mostly about first-generation drugs, that indicated GLP-1 agonists may promote bone formation by increasing osteoblast differentiation and survival while reducing ...

A transformative study has uncovered the pivotal role of the protein Naked cuticle homolog 2 (NKD2) in regulating the differentiation of bone-forming osteoblasts and bone-resorbing osteoclasts ...

Role of RANKL in differentiation, fusion, activation and survival of osteoclasts. Osteoclast differentiation is a multistep process. Myeloid progenitor cells progressively differentiate into ...

Osteoclasts derive from a myeloid progenitor that gives rise to both the monocyte-macrophage lineage and the osteoclast lineage. A mononuclear pre-osteoclast exists that expresses both TRAP and CTR.

Excessive osteoclast activity can lead to increased bone resorption, which contributes to osteoporosis. The findings revealed that iSN40 completely inhibits the differentiation of osteoclast ...

Excessive osteoclast activity can lead to increased bone resorption, which contributes to osteoporosis. The findings revealed that iSN40 completely inhibits the differentiation of osteoclast ...

Using a multifaceted approach, we identified a metabolomic signature of osteoclast differentiation consisting of increased amino acid and nucleotide metabolism. Maintenance of the osteoclast metabolic ...

Targeting osteoclast differentiation is therefore, a potential therapeutic strategy. In a new study, researchers have discovered a novel role of the Ctdnep1 phosphatase in suppressing osteoclast ...

During osteoclast differentiation, Ctdnep1 expression remains consistent, yet its depletion results in heightened osteoclast formation and activity. Mechanistically, Ctdnep1 demonstrates a ...