Osteogenic differentiation is essential for bone development, metabolism, and repair; however, the underlying regulatory relationships among genes remain poorly understood. To elucidate the ...

Extracellular matrix proteins have been implicated in the regulation of osteoblast differentiation of bone marrow derived mesenchymal stem cells (BMSCs) through paracrine or autocrine mechanisms. In ...

Researchers have developed a novel compound that could be useful for treating bone-destructive diseases. Their study ...

Oxidized atherogenic lipoproteins stimulate vascular calcification by driving osteoblastic differentiation of vascular smooth muscle cells while inhibiting osteoclast differentiation of macrophages ...

Bone-destructive diseases such as osteoporosis and chronic inflammatory arthritis affect millions of people worldwide, ...

He referenced preclinical data, mostly about first-generation drugs, that indicated GLP-1 agonists may promote bone formation by increasing osteoblast differentiation and survival while reducing ...

Pre-neurogenic (N)-RPC, early RPC and late RPC clusters are labeled. (C) Schematic illustration of the bell curve-like distribution of rod photoreceptor differentiation and glycolytic activity, which ...

† ShenZhen Research Institute, Sun Yat-Sen University, ShenZhen, 518057, People’s Republic of China ‡ Guangzhou Quality R&D Center of Traditional Chinese Medicine, Guangdong Key Laboratory of Plant ...

Abnormalities in the differentiation process can lead to consequences, such as impaired tissue regeneration and the development of certain cancers. Led by Lars Velten, PhD, group leader at the ...

Even though both sex differentiation in the brain and the development of testes start with the same gene, Sry, this research shows that the signaling pathways differ. In the brain, the signaling ...