These resorption and formation phases are ... Using this method, they explored the interplay between bone-destroying osteoclasts and bone-forming osteoblasts. However, the spatial resolution ...

Understand why menopause causes bone density loss in women. Learn the hormonal changes responsible and effective strategies ...

Researchers have developed a novel compound that could be useful for treating bone-destructive diseases. Their study ...

The findings revealed that proteins named Rab32 and Rab38 play pivotal roles in bone resorption in osteoclast, cell specialized in the process. These proteins are also crucial for pigmentation of ...

The new understanding provided by the RANK/RANKL/OPG paradigm for both differentiation and activation of osteoclasts has ... characterized by excessive bone resorption. Cite this: Osteoprotegerin ...

These conditions often result from the dysregulation of osteoclasts—specialized ... for building new bone—suggesting a highly targeted effect on bone resorption without compromising bone ...

"Our findings suggest that Opto-RANK can be used to induce macrophage differentiation into osteoclasts and stimulate local bone resorption when activated by blue light," says Nakata. The precise ...

Their research has found that mechanosensitive protein polycystin-1 (PC1, encoded by Pkd1) plays an important role in osteoclast-mediated bone resorption. The authors conducted a cohort study of ...

Bone is resorbed by specialized cell called osteoclast, and several substances are secreted out to the pits where osteoclast attaches to bones and resorption occurs, like acids (H +) and degrading ...