Bone-destructive diseases such as osteoporosis and chronic inflammatory arthritis affect millions of people worldwide, ...

A recent study identifies Neural EGFL-like 2 (NELL2), a secreted protein, as a key regulator of bone homeostasis, offering ...

Most importantly though, they contain both osteoclasts and osteoblasts, the cells that respectively clear away broken bone fragments and generate new bone after a fracture. Explains Kobayashi-Sun ...

Bortezomib may increase osteoblast activity but it is unclear ... agents alter abnormal bone metabolism in MM, inhibiting osteoclast function. Novel agents under evaluation, targeting the RANKL ...

Panel A shows osteoclasts and osteoblasts in normal bone (toluidine blue, ×100). The large osteoclast is actively resorbing bone. Osteoblasts are small, cuboid cells that actively lay down bone ...

Osteoblasts and osteoclasts are two types ... indicating its cytoplasmic function in osteoclast differentiation. Further, ...

Although, bone remodeling by osteoblasts and osteoclasts is crucial for maintaining ... "Our study shows Gprc5a may function as a negative feedback factor for the bone formation promoting effect ...

These conditions often result from the dysregulation of osteoclasts—specialized ... Additionally, it did not disrupt the function of osteoblasts—the cells responsible for building new bone ...