On-chip vascular bed (VB) system, which enables a three-dimensional tissue to be cultured on a perfusable vasculature, is useful to overcome the current limitation of a kidney organoid (KO): the lack ...

Researchers have created liver tissue that grows its own blood vessels, improving research into hemophilia and liver damage.

Organoid cultures have emerged as an alternative in vitro system to recapitulate tissues in a dish. While mouse models and cell lines have furthered our understanding of liver biology and associated ...

The studies included in this review were required to meet the following criteria: (1) Study Focus: The research must involve the application of organoid technology in skeletal-related diseases; (2) ...

In mice that mimic hemophilia, the study showed that organoid-derived Factor VIII rescued them from severe bleeding. Potential Application Beyond Liver Organoids: By developing IMALI culture methods ...

The current research models of breast cancer are usually limited in their capacity to recapitulate the tumor microenvironment in vitro. The lack of an extracellular matrix (ECM) oversimplifies ...

Further investigations prove that adhesion-based spatial mechanical stimulation from the ECM mimic hydrogel enhances multidirectional differentiation of BMSCs-based organoid via Yap/Tead4 ...

This valuable study reports the development of a novel organoid system for studying the emergence of autorhythmic gut peristaltic contractions through the interaction between interstitial cells of ...

High-throughput systems that integrate brain organoids with microfluidics, known as organoid-on-a-chip systems, are revolutionizing their application in research and drug discovery (Anderson et al., ...