The RNA cloud formed around genes regulates their readout into RNA. Triplexes help define where in the genome a cloud forms. Proteins and other fl ...

A study by scientists at the Herbert Irving Comprehensive Cancer Center (HICCC) introduces a more cost-effective, scalable ...

In this work, we investigate the ability of TDG to excise modified nucleobases from the simplest unit of compacted DNA, the nucleosome core particle (NCP). We measure TDG activity on a population of ...

This study provides valuable findings on the role of site-specific DNA methylation changes during spermatogenesis and their contribution to paternal epigenetic inheritance. The study proposes that ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Locusts, as devastating pests, can reversibly ...

One chromatin remodeling mechanism called "nucleosome sliding" allows a nucleosome to be "moved" to control gene access, but how this works has been incompletely understood. To address this gap ...

Note that clear and well-separated dots are visualized with single-step photobleaching profiles (Fig. 3C), suggesting that each dot represents a single H3.2-Halo-JF646 molecule in a single nucleosome.