Researchers have used a personalised base-editing gene therapy to successfully treat an infant with carbamoyl-phosphate ...

A unique feature of HR is that it repairs the damage to the DNA in a highly accurate way. In eukaryotic cells (those with a ...

In Biology 101, we learn that RNA is a single, ribbon-like strand of base pairs that is copied from our DNA and then read like a recipe to build a protein. But there's more to the story. Some RNA ...

For instance, he was the first to discover the order of the three major components of a single nucleotide (phosphate-sugar-base); the first ... C with G), with each pair held together by hydrogen ...

Somatic hypermutation (SHM) of immunoglobulin variable (V) regions modulates antibody-antigen affinity is initiated by activation-induced cytidine deaminase (AID) on single-stranded DNA (ssDNA).

and Asp-56 are situated close enough to contact the phosphate backbone or the unpaired nucleotide base through water-mediated interactions and may contribute to maintaining a unique DNA conformation.

We introduce MADna, a sequence-dependent coarse-grained model of double-stranded DNA (dsDNA), where each nucleotide is described by three ... bonded interactions involve at most two consecutive base ...

Early research shows that editing expanding trinucleotide repeats halts the lengthening process that causes neurological ...

The authors created a useful collection of Rep protein variants with changes that alter the amino acid sequence, but these did not lead to clear improvements in how the virus worked. Instead, their ...

Life is thought to have begun when RNA began replicating itself, and researchers have got close to achieving this in the lab ...

Beam is a pioneer of the base-editing approach to gene-editing, which can be used to convert one nucleotide base into another without cutting both strands of DNA, unlike other technologies like ...