A unique feature of HR is that it repairs the damage to the DNA in a highly accurate way. In eukaryotic cells (those with a ...

and Asp-56 are situated close enough to contact the phosphate backbone or the unpaired nucleotide base through water-mediated interactions and may contribute to maintaining a unique DNA conformation.

We introduce MADna, a sequence-dependent coarse-grained model of double-stranded DNA (dsDNA), where each nucleotide is described by three ... bonded interactions involve at most two consecutive base ...

Early research shows that editing expanding trinucleotide repeats halts the lengthening process that causes neurological ...

The authors created a useful collection of Rep protein variants with changes that alter the amino acid sequence, but these did not lead to clear improvements in how the virus worked. Instead, their ...

Life is thought to have begun when RNA began replicating itself, and researchers have got close to achieving this in the lab ...

The yeast nuclear endonuclease Rnt1 has a well-characterized role in the maturation of many ncRNA precursors. However, the scope and consequence of its function in mRNA degradation pathways is much ...

Co-paired stars, or stars that travel together, can provide insights into processes that other stars can't. Differences in their brightness, orbits, and chemical composition can hint at different ...

Beam is a pioneer of the base-editing approach to gene-editing, which can be used to convert one nucleotide base into another without cutting both strands of DNA, unlike other technologies like ...

Typically miRNAs interact with specific mRNAs through complementary base-pairing to influence the translation or stability of the target mRNA molecule. Beck et al. conducted single-cell and ...

A new memorandum has firmed up China and Russia's intent to lead the construction of a new lunar base to be completed by 2036, as NASA talks about scaling back its own lunar ambitions. A new ...

Department of Biochemistry and Biophysics, Arrhenius Laboratory, Stockholm University, S-106 91 Stockholm, Sweden, and LightUp Technologies AB, Lunastigen 5, S-141 44 Huddinge, Sweden Article Views ...