MicroRNA-27a has been shown to stimulate both the wingless-type integration site family, or Wnt signaling, and the bone morphogenetic protein pathways to actively promote bone regeneration, according ...

Sunshine Biopharma Inc. has completed additional studies on orthotopic human tumor models in mice confirming its K1.1 mRNA lipid nanoparticle (K1.1-mRNA-LNP) product as a novel therapeutic agent for ...

Additionally, mRNA expression lasted up to four weeks -- significantly longer than the typical five-day expression period of LNPs. Notably, the polymer ensured mRNA expression only at the ...

A mathematically controlled comparison shows that in physiologically relevant parameter regimes, feedback regulation through the mRNA provides the best suppression of expression noise. Consistent with ...

we rely on other databases for the expression data. The first-priority database for RNA-seq gene counts is ARCHS4 (Human, Mouse, and Zoo versions), which covers 35,088 datasets. The other source is ...

Nonetheless, challenges remain with regards to mRNA stability, duration of expression, delivery efficiency, and targetability, to broaden the applicability of mRNA therapeutics beyond COVID-19 ...

In mouse and pig models ... specific modified mRNA translation system — which the UAB researchers call “cardiomyocyte SMRTs.” This system, developed by Zhang and colleagues, can be used to upregulate ...

Another group of six mice got a nanoparticle with the same mRNA payload, but with no targeting sugar on its surface; six other mice got the upgraded nanoparticle but with mRNA inside that didn’t code ...

In the last few decades, scientific literature has reported new technologies such as single-cell transcriptomics, humanized mice and organoids ... From the aborted fetuses, thymus, liver, spleen ...