Furthermore, a global lack of T cell tolerance to murine and human self antigens is a major driver of autoimmune disease among HIS mice whose T cells develop in a murine thymus ... to Hu/Hu mice may ...

“Our discovery—the regulatory T cell recirculation back to the thymus—promotes repair through a process that hasn’t been described before and represents a novel pathway to regeneration ...

The team's study results, published today in the journal Immunity, outline their discovery of a specific type of regulatory T cell that can home back into the thymus and repair the organ when it's ...

Indeed, we are the first ever to have administered Treg cell therapies to patients and the first company to begin receiving revenues from sales of our lead product; so far, 27 patients have been ...

miPEP31, encoded by the primary transcript of miR‐31, is a cell‐penetrating peptide which promotes Treg differentiation ... Immunoblot analysis of multiple mouse tissues with a specific antibody ...

After acute injury to the thymus in their mouse models, Rac1 GTPase inhibitor increased cellularity in the thymus while simultaneously decreasing mir29 activity and, excitingly, increasing IL-23 and ...

Binding of TCRs to self-peptide-loaded MHC molecules (self-pMHC) in the thymus leads to positive selection ... Figure 1 Schematic landscape of Treg in the elderly. During human and mouse aging, there ...

The researchers have found that female sex hormones instruct important changes in the thymus, a central organ of the immune system, to produce specialized cells called Tregs to deal with ...

Regulatory T cells (Tregs), traditionally recognized as potent suppressors of immune response, are increasingly attracting attention because of a second major function: residing in parenchymal tissues ...