Progenitors of intraepithelial T cells (IELps) migrate from the thymus to the intestines after ... and see effective tumor control in mouse models, thereby hinting potential clinical translation.

Using single-cell RNA sequencing and mRNA translation analysis, we identified CD4 + tissue-resident memory ... migrate from the thymus to the intestines after birth where they can develop into ...

(A) HIS mice with mouse thymus were generated as described in Materials and ... After 6 days, cells were stained with antibodies against human CD3, CD4 and CD8 and analyzed with a flow cytometer.

CD8 T cells lacking Tet1/3 preferentially differentiate into short-lived effector and effector memory cells following acute ...

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HIS mouse) model, demonstrating the importance of CD4+ Tfh and Tph cells for the disease onset. They clarified the conditions under which these T cells become reactive using techniques involving the ...

Thymically committed regulatory CD4 T cells (tTregs) are essential for immune homeostasis ... This result suggested a higher activity for most of the “private” genes in the thymus when compared to the ...