Structure-based drug design is the design ... the SARS-CoV-2 PLpro protease shows strong efficacy in a mouse model, preventing lung pathology and reducing brain dysfunction. The study provides ...

Connections made via apical synapses seemed to be strengthened by movement information more than those made via basal ...

From a cubic millimeter of brain tissue, scientists have constructed a precise, 3D map of the activity in a mouse’s brain, detailing 84,000 neurons and more than 500 million synapses.

WASHINGTON — Thanks to a mouse watching clips from “The Matrix,” scientists have created the largest functional map of a brain to date – a diagram of the wiring connecting 84,000 neurons as they fire ...

Because they had studied how the mouse’s neurons lit up as it watched videos, the team could compare the neurons’ mapped structure with their functions and piece together how the connections between ...

The 3D blueprints show more than two miles of neural wiring, close to 100,000 nerve cells, and about 500 million synapses — all contained in a piece of mouse brain no bigger ... AI and the end results ...

The influence of fibrotic tissue was also modeled. The digital twins simulating normal and diseased lung structure and function were then used to study the delivery and distribution of PRS-220 ...

Scientists achieved “a milestone” by charting the activity and structure of 200,000 cells in a mouse brain and their 523 million connections. A neuron extends an axon to make contact with ...

Researchers from the Guangzhou Institutes of Biomedicine and Health, part of the Chinese Academy of Sciences, have developed a detailed spatiotemporal atlas of mouse lung development, uncovering ...

Get Instant Summarized Text (Gist) A comprehensive spatiotemporal atlas of developing mouse lungs has been constructed, revealing new molecular and cellular mechanisms in pulmonary organogenesis ...

A human histidyl-tRNA synthetase splice variant therapeutic targets NRP2 to resolve lung inflammation and fibrosis. Science Translational Medicine , 2025; 17 (789) DOI: 10.1126/scitranslmed ...