After obtaining an entire elastic lung model, I will run particle deposition studies on a technology called the Next Generation Impactor (NGI) and analyze the deposition of particles from an inhaler.

The development of animal models of lung cancer is critical to our understanding and treatment of the human disease. Conditional mouse models ... Intratracheal delivery provides the most direct ...

For gene therapy to work well, therapeutic molecules need to be efficiently delivered to the correct locations in the body—a ...

Researchers have reversed lung fibrosis in a mouse model of idiopathic pulmonary fibrosis ... a medication approved by the United States Food and Drug Administration for use in several forms ...

On the day after the final injection, we killed the mice by CO 2 asphyxiation and obtained spleens, lungs, bone marrow and peritoneal exudate cells from each mouse. We pooled tissues of the same ...

How effectively this works can get complicated, depending on the drug, delivery method and patient ... Fromen and two UD alumni have developed an adaptable 3D lung model that can replicate realistic ...

and colleagues used a lung-targeted CRISPR-Cas9 drug delivery strategy to knock down cyclin-dependent kinase 4 (CDK4) in tumors, resulting in synthetic lethality in a KRAS-mutant mouse model of ...

For this, they used a mouse line that carries ... exciting,” said Gaurav Sahay, a drug delivery scientist at Oregon State University. According to him, the LNPs’ ability to deliver gene-editing ...

Gliptin treatment sped up recovery in several mouse models of lung injury. But these oral drugs do not easily enter the organ; researchers had to use very high doses, which made repurposing ...

When you swallow a pill, only a fraction of the drug ends up where it’s needed. Active compounds diffuse across the intestinal wall and are diluted in rivers of blood, aimlessly drifting with the ...

and Model Medicines is working on one compound to kill them all. The AI drug discoverer’s oral small molecule was able to reduce SARS-CoV levels in the lungs of infected mice and also ...

An experimental drug now in clinical trials as a cancer ... Johns Hopkins Medicine investigators report, based on mouse-model research of the lung-damaging disease. Findings from the study ...