Neuroscientists can now make precise genetic tweaks to the neurons that are most affected by brain diseases such as Parkinson ...

This study presents valuable findings on the patterned loss of Purkinje cells in the mouse cerebellum during aging. Convincing evidence shows that Purkinje cell loss with aging occurs in a pattern of ...

Purkinje cell (PC) dendrites are optimized to integrate the vast cerebellar input array and drive ... two primary dendrites ramified parallel with the PC layer for >300 µm in human (>150 µm in mouse), ...

Collectively called volume electron microscopy, or volume EM, these methods use electron microscopes to image thin layers of ... cilia on granule cells in the mouse cerebellum.

We selectively increased the excitability of molecular layer interneurons (MLIs) to suppress Purkinje cell firing in the mouse cerebellar vermis. Chemogenetic perturbation of MLIs impaired SRM without ...

PCs receive two excitatory inputs, the CFs coming from IONs in the brainstem and the PFs coming from the GCs in the granular layer of the cerebellar cortex, and two inhibitory inputs coming from ...

The expression of ATOH1 and NEUROD1 distinguishes two different progenitor maturation stages in the developing cerebellar external granule cell layer. CCND1/CDK4‐mediated ... ChIP assay in P7 mouse ...

Further investigation demonstrated that the cerebellum of the mutant mouse has lost most of its Purkinje cells, while other cerebellar cells ... The soma of PC is located between the outer molecular ...

In mouse cerebellum from 0 to 8 postnatal days the proportion of pyknotic (presumed dead or dying cells) was always <0.5%; most were located in the deep EGZ adjacent the molecular layer and it was ...

The brains of apes and humans evolved unusually quickly when it came to the cerebellum, a part of the brain involved in control of movement, researchers say. The finding may change what is ...