Cerebellar rhythm loss due to climbing fiber regression is a shared pathophysiology of motor deficits across cerebellar ...

Using an unbiased approach, this important study discovered a role of Ezh2 in the differentiation of granule neuron precursors, the cell of origin for Shh group of medulloblastoma. Furthermore, the ...

Huntington's disease is a rare genetic, autosomal dominant, neurodegenerative disease, caused by CAG repeat expansions in the HTT gene, that is polymorphic on the healthy allele and contains more than ...

Oct. 24, 2024 — Researchers studied what happens immediately after a stroke in the stem cell niche known as the subventricular zone, using a mouse model ... with the cerebellum being critical ...

Dyrk1A has also been implicated in cerebellar abnormalities observed in association with DS, and normalization of Dyrk1A dosage rescues granular and Purkinje cell densities in a trisomic DS mouse ...

However, the link between stress-induced microglia reactivity and cerebellar dysfunction is missing. Here, we investigate the developmental immune environment in translational mouse models that ...

Mouse models, as demonstrated, provide a powerful model system to further explore the contribution of cerebellar dysfunction to sensorimotor and cognitive/behavioral dysfunction in patients with ASD.