Bile acids affect the expression of a chemokine ligand by liver sinusoidal endothelial cells, ... In a series of experiments in mouse models, ...

Bile acids are molecules produced by the liver and used by the gut to help digest food and absorb cholesterol, fats, and nutrients. In 2019, Evans and his colleagues showed in mice how high-fat ...

Reduction in hepatic secondary bile acids caused by short-term antibiotic-induced dysbiosis decreases mouse serum glucose and triglyceride levels. Scientific Reports , 2018; 8 (1) DOI: 10.1038 ...

The drug improved bile composition and reduced inflammation and fibrosis in a mouse model by targeting two ABC transporters, ABCB4 and BSEP. Rectify Pharma is using its ABCs to treat PSC.

In studies in mice, researchers report they have found that bilirubin, a bile pigment most commonly known for yellowing the skin of people with jaundice, may play an unexpected role in protecting ...

In the distal ileum, FXR, activated by bile acids, induces expression of the FGF19 gene in humans. ... The authors caution that human and mouse bile acid profiles differ in important ways.

Bile duct cancer is a rare but aggressive form of cancer, affecting just over 2,000 people in the UK every year. However, incidences of bile cancer are steadily increasing every year – with some ...