A research team from the Medical University of Vienna has made further progress in the treatment of intestinal inflammation.

While studying mouse and human liver tumors, they discovered that certain bile acids in the liver could affect the activity of cancer-fighting immune cells, called T cells. The researchers ...

examined the effects of bile acids on energy expenditure in mice, and in cultured mouse and human cells. The team found that administering cholic acid—a bile acid—to mice on a high-fat diet ...

We have, therefore, developed a BAAT knockout mouse in our lab that lacks these taurine- and glycine-conjugated bile acids. By introducing MCBAs to the guts of these BAAT knockout mice ...

while the bile acid that inhibits FXR acts as fuel for the tumors. These results were consistent across mouse models of colon cancer the researchers studied, along with organoids—lab-grown ...