There have been important recent advances in the management of Crohn's disease, including new classes of biological or small molecule therapies, an appreciation that endoscopic mucosal healing results ...

A new study, published today in Nature Communications, offers clues into how APOE isoforms differentially affect human ...

Here, we discuss the ontogeny, function, and interplay of tissue-resident and monocyte-derived macrophages in various organs ... patterns released by dying cells and subsequently produce cytokines, ...

The study 'Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages' led ... of messenger substances, so-called cytokines, that can activate numerous immune ...

In our cohort, two vaccinations were required for the release of significant amounts of cytokines in stimulated cells suggesting the induction of a memory response by the first priming vaccine in ...

and NF-κB2 in human monocytes and restore their impaired cytokine secretion in a platelet:monocyte ratio-dependent manner. Our findings elucidate the pivotal role of platelet-derived TFs in regulating ...

Microglia, an immune cell population within the central nervous system which phagocytose cell debris and modulate the immune response via cytokine signaling ... Upon activation, both microglia and ...

Macrophage cytokine responses to inflammatory stimuli are also of ... Summary diagram of effects of CDK9 inhibition and activation on inflammatory pathways in monocyte-derived macrophages. Activation ...

and also bore higher neutrophil and inflammatory cytokine levels, which could be the direct result of knockdown or as a consequence of greater viral load. Fewer monocytes or monocyte-derived ...

The team showed that 24-hour stimulation with the full-length mammalian cell-derived S1 subunit ... in THP1 monocytes. There were similar changes in cytokines noted in healthy donor peripheral ...

7 Although cytokine storm is easy to identify ... Macrophages, which are tissue-resident cells that are often derived from circulating monocytes, do not divide; they have diverse functions ...