There have been important recent advances in the management of Crohn's disease, including new classes of biological or small molecule therapies, an appreciation that endoscopic mucosal healing results ...

Conclusion Our study reveals a critical role for monocyte-derived MΦs in restoring intestinal homeostasis after surgical trauma. From a therapeutic point of view, our data indicate that inappropriate ...

Federally funded Johns Hopkins team finds the virus ‘reprograms’ neutrophils to impair production of immune cells critical ...

Shared neoantigens, derived from recurrent mutations found across multiple patients, are considered to be a challenging, but promising approach. Here we analyzed shared frameshift neoantigens derived ...

(Created in BioRender.com). SARS-CoV-2 infects host cells and activates immune cells, such as neutrophils, monocytes, macrophages, NK cells, T cells, DCs, etc. Those immune cells release cytokines ...

Numerous inflammatory cytokines have been implicated in the pathogenesis of cardiovascular diseases. Monocyte chemoattractant protein (MCP)-1/CCL2 is expressed by mainly inflammatory cells and stromal ...

Specifically, we observed that macrophages derived from blood-circulating monocytes are rapidly drawn to the wound area following perforation. In parallel with the macrophage recruitment, we captured ...