Mitochondrial homeostasis is crucial for the maintenance of cellular equilibrium. In neurons, which are non-regenerative cells, mitochondrial dysfunction ...

One of the studies in this topic characterized a novel pathogenic variant of the ACO2 gene, which encodes aconitase 2, a mitochondrial enzyme essential for the TCA cycle and mitochondrial DNA ...

An interdisciplinary research team led by Professor Dr. Bent Brachvogel has examined how mitochondria influence the premature ...

The POLG gene regulates the production of DNA polymerase gamma, an enzyme that copies mitochondrial DNA. Without it, the mitochondria cannot function normally and, as a result, fail to provide the ...

When the mechanisms that replicate or repair mitochondrial DNA (mtDNA) fail, it can cause a wide range of syndromes for which there are few to zero existing treatment options. One of the causes of ...

Fifty years since its discovery, scientists have finally worked out how a molecular machine found in mitochondria, the ...

Damage to the genetic material of mitochondria – the mitochondrial DNA or mtDNA for short – can lead to diseases such as Parkinson’s, Alzheimer’s, amyotrophic lateral sclerosis (ALS), cardiovascular ...

An international research team has provided a detailed insight into how the spatial organization of genetic material is established in the cell nucleus of early embryos within the first hours after ...