sensing and resulting inflammatory pathology should have important implications for understanding the mitochondrial aetiology of human disease and ageing. Mitochondrial DNA (mtDNA) — which is ...

Defects of mitochondrial DNA (mtDNA) maintenance and mitochondrial ... dysfunction is a novel concept in mitochondrial pathology and may have important implications for understanding tissue ...

Results from a new study help resolve the decade-long mystery of why many patients with the deadliest form of skin cancer do ...

They contain DNA inherited from one's mother ... genetic and environmental factors known to impact mitochondrial disease pathology." The researchers found that reactive oxygen molecules produced ...

Scientists have found DNA in the nucleus of brain cells ... this suggests that numtogenesis might be a way that mitochondrial dysfunction leads to pathology and contributes to conditions that ...

Damaged mitochondrial DNA (mtDNA) initiates and spreads Parkinson's disease (PD) pathology, potentially opening new avenues for early diagnosis, disease monitoring, and drug development.

Some of these conditions result from mutations in mitochondrial DNA (mtDNA), the genetic material ... improving their potential for studying mutation pathology. This enhanced efficiency also ...

Mutations in mitochondrial DNA, or mtDNA, torpedo the process, leading to sluggish cells that eventually wither away. Some mitochondrial DNA mutations have been linked to age-related diseases, ...

Scientists have shown that in one in every 4,000 births, some of the genetic code from our mitochondria—the 'batteries' that power our cells—inserts itself into our DNA, revealing a surprising ...

ATP-production is essential for vesicle docking, fusion and endocytosis. Mitochondrial pathology and some treatments affect the mitochondrial membrane potential. Disrupting the MMP results in more ...

You can read “Mitochondrial DNA damage triggers spread of Parkinson's disease-like pathology “ in Molecular Psychiatry. The authors declare no competing interests. Disclaimer: AAAS and EurekAlert!

Because of this history, mitochondria still have their own ring-shaped DNA—completely separate from the 23 chromosomes that make up most of the human genome. And although those chromosomes come ...