This unique profile of changes is compatible with the action of mirtazapine at 5-HT-2 receptors, at presynaptic adrenergic alpha 2 receptors, at the HPA system, and on ghrelin and leptin.

The researchers looked at one type of serotonin receptor called 5HT2a, thought to be involved in causing antidepressant side effects. Mirtazapine completely blocks this receptor, so the ...

For example, some suggest that mirtazapine-induced weight gain may be secondary to its effects on the 5-HT2C and H1 receptors. [2] Certain antidepressants in general may induce weight gain ...

Mechanism of Action Mirtazapine affects a variety of neurotransmitters, including serotonergic, adrenergic, histamine, and muscarinic receptors. In affecting the 5HT-2 serotonergic, but not ...

Mirtazapine is a central alpha-2 antagonist currently FDA-approved for the treatment of major depressive disorder. The antidepressant mirtazapine appears to be a safe and effective treatment ...

Mirtazapine is a prescription medicine used in the treatment of depression. This medicine helps by increasing the level of ...

They randomly assigned patients in a 1:1:1 ratio to receive either 7.5 mg/d mirtazapine (n = 27), 10 mg/d amitriptyline (n = 26), or placebo (n = 27) for 16 weeks, starting with one tablet per ...